Scientists carried out various tests using mice, where the ability of the SCUBE3 signaling molecules to activate the follicles could be observed.
An international group of researchers discovered a signaling molecule, called ‘SCUBE 3 ‘, which is responsible for stimulating hair growth, being useful for the development of potential treatments to combat androgenetic alopecia, which causes hair loss, reported the University of California, Irvine (UCI, for its acronym in English ).
According to those responsible for the study, published in the journal Developmental Cell, the exact mechanism was identified when the cells of the dermal papilla generate signals in the lower part of the hair follicles to encourage new hair growth.
“We reveal that the signaling molecule SCUBE3, which is naturally produced by dermal papilla cells, is the messenger used to
‘say’ to the cells neighboring hairy stems to start dividing, which heralds the start of new hair growth,” commented Maksim Plikus, professor at UCI.
Using mice to test the effectiveness of SCUBE3
After learning that the production of SCUBE3 molecules is essential for hair growth in mice and humans , the researchers designed a rodent model, which had dermal papilla cells to hyperactive, which, as a result, developed excess hair.
“Studying this mouse model allowed us to identify SCUBE3 as the previously unknown signaling molecule that can drive excessive hair growth,” said scientist Yingzi Liu.
Subsequently, SCUBE3 was validated in experiments with human follicles. In further tests, the scientists injected SCUBE 3 into the skin of a mouse, into which follicles from a human scalp had been transplanted. This caused a powerful stimulation of hair growth, both in the human follicles that were inactive and in the mouse follicles that surrounded them.
“These experiments provide data that prove the principle that SCUBE3, or derived molecules, may be a promising therapy for hair loss,” said researcher Christian Guerrero-Juarez.
Finally, Plikus stated that “there is a There is a great need for new and effective drugs for hair loss, and natural compounds that are normally used by dermal papilla cells present themselves as ideal candidates for next-generation treatment”, so the “test in the transplant model of human hair validates the potential” of the SCUBE3 molecule.
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